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CS-W001157 4
Total: USD 88.00

tert-Butyl 4-(3-aminophenyl)piperidine-1-carboxylate

  • CAS No. 387827-19-2

  • Cat. No. CS-0048261
  • Molecule weight276.37
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 4-(3-aminophenyl)piperidine-1-carboxylate|CS-0048261

Structure of 387827-19-2

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General Information

  • CAS No. 387827-19-2
  • Cat. No. CS-0048261
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₂₄N₂O₂
  • Molecular Weight 276.37
  • Synonym(s) 4-(3-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
  • SMILES CC(C)(C)OC(=O)N1CCC(CC1)C1=CC(N)=CC=C1

Description

tert-Butyl 4-(3-aminophenyl)piperidine-1-carboxylate features a piperidine core bearing a para-aminophenyl group and a tert-butoxycarbonyl protecting group. This compound integrates readily into medicinal chemistry workflows, enabling direct access to bioactive analogs through deprotection or further functionalization. The electron-rich aromatic amine supports efficient coupling reactions, while the tert-butyl carbamate ensures stability during purification and storage.

Application

tert-Butyl 4-(3-aminophenyl)piperidine-1-carboxylate serves as a versatile building block for the synthesis of bioactive piperidine-containing compounds. The tert-butyl carbamate group provides excellent stability and ease of removal under mild acidic conditions, while the meta-aminophenyl moiety enables direct functionalization or incorporation into heterocyclic scaffolds. Its compatibility with standard coupling reactions and broad functional group tolerance make it ideal for medicinal chemistry campaigns targeting CNS-directed therapeutics and kinase inhibitors.

Synthesis

  • Route1
    • tert-Butyl 4-(3-aminophenyl)-5,6-dihydropyridine-1(2H)-carboxylate|CS-0160999
      387827-18-1
    • ~84%
    • In-stock
      tert-Butyl 4-(3-aminophenyl)piperidine-1-carboxylate|CS-0048261
      387827-19-2

    References

    • US2004/38855 A1, ;
  • Route2
    • null|null
      138647-55-9
    • ~86%
    • In-stock
      tert-Butyl 4-(3-aminophenyl)piperidine-1-carboxylate|CS-0048261
      387827-19-2

    References

    • WO2006/10446 A2, ; Page/Page column 37 ; WO 2006/010446 A2
  • Route3
    • tert-Butyl 4-(3-aminophenyl)-5,6-dihydropyridine-1(2H)-carboxylate|CS-0160999
      387827-18-1
    • null|null
      75-31-0
    • ~86%
    • In-stock
      tert-Butyl 4-(3-aminophenyl)piperidine-1-carboxylate|CS-0048261
      387827-19-2

    References

    • US2003/69261 A1, ; US 20030069261 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   55.56
  • LogP   3.3833
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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