tert-butyl 4-(4-amino-3-methylphenyl)piperidine-1-carboxylate

Name: tert-butyl 4-(4-amino-3-methylphenyl)piperidine-1-carboxylate
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CAS No. 1383682-59-4
Cat. No. CS-W018395
Molecule weight290.40
Purity≥98%
MDL No.MFCD30294365

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tert-butyl 4-(4-amino-3-methylphenyl)piperidine-1-carboxylate|CS-W018395

Structure of 1383682-59-4

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General Information

CAS No. 1383682-59-4
Cat. No. CS-W018395
Purity ≥98%
MDL No. MFCD30294365
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₇H₂₆N₂O₂
Molecular Weight 290.40
Synonym(s) 4-(1-Boc-piperidin-4-yl)-2-methylaniline
SMILES Cc1cc(ccc1N)C1CCN(CC1)C(=O)OC(C)(C)C

Description

tert-Butyl 4-(4-amino-3-methylphenyl)piperidine-1-carboxylate features a piperidine core functionalized with a para-amino-meta-methyl aniline moiety, delivering enhanced solubility and stability under standard conditions. The tert-butyl ester group enables straightforward deprotection in acidic environments, facilitating integration into diverse synthetic sequences. This scaffold serves as a key intermediate for bioactive compound development.

Application

tert-Butyl 4-(4-amino-3-methylphenyl)piperidine-1-carboxylate serves as a versatile building block for the synthesis of biologically active compounds, enabling efficient access to substituted piperidine scaffolds. The protected amine and aromatic functionality offer orthogonal reactivity, facilitating downstream transformations such as Suzuki-Miyaura coupling, reductive amination, or amide formation. Bench-stable and readily purified by standard chromatography, it functions as a key intermediate in medicinal chemistry campaigns targeting CNS modulators and kinase inhibitors.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 55.56
LogP 3.69172
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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tert-butyl 4-(4-amino-3-methylphenyl)piperidine-1-carboxylate

CAS No. 1383682-59-4

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