tert-Butyl 4-(4-amino-3-fluorophenyl)piperidine-1-carboxylate

Name: tert-Butyl 4-(4-amino-3-fluorophenyl)piperidine-1-carboxylate
Brand: ChemScene
Availability: InStock
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CAS No. 1488342-80-8
Cat. No. CS-0096060
Purity≥95%
MDL No.MFCD26687265

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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tert-Butyl 4-(4-amino-3-fluorophenyl)piperidine-1-carboxylate|CS-0096060

Structure of 1488342-80-8

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Description

tert-Butyl 4-(4-amino-3-fluorophenyl)piperidine-1-carboxylate features a fluorinated aromatic ring paired with a piperidine scaffold, enabling integration into bioactive molecules. This bench-stable derivative delivers a key pharmacophore for medicinal chemistry applications, combining enhanced solubility and metabolic stability in synthetic workflows.

Application

tert-Butyl 4-(4-amino-3-fluorophenyl)piperidine-1-carboxylate serves as a versatile building block for medicinal chemistry campaigns, enabling direct incorporation of a fluorinated aniline motif into piperidine-based scaffolds. The tert-butyl carbamate group provides excellent bench stability and facilitates straightforward deprotection under mild acidic conditions. It functions reliably in standard coupling reactions and supports diverse downstream modifications, including reductive amination and amide formation, making it ideal for rapid lead optimization in API development.

General Information

CAS No. 1488342-80-8
Cat. No. CS-0096060
Purity ≥95%
MDL No. MFCD26687265
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₆H₂₃FN₂O₂
Molecular Weight 294.36
Synonym(s) 1-Piperidinecarboxylic acid, 4-(4-amino-3-fluorophenyl)-, 1,1-dimethylethyl ester
SMILES O=C(N1CCC(C2=CC=C(N)C(F)=C2)CC1)OC(C)(C)C

Computational Chemistry Data

TPSA 55.56
LogP 3.5224
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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tert-Butyl 4-(4-amino-3-fluorophenyl)piperidine-1-carboxylate

CAS No. 1488342-80-8

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