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CS-W001157 4
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3-Bromo-7,8-dihydro-1,6-naphthyridin-5(6H)-one

  • CAS No. 301666-81-9

  • Cat. No. CS-0108565
  • Purity≥98%
  • MDL No.MFCD18073519

*For research and further manufacturing use only, not for direct human use.

3-Bromo-7,8-dihydro-1,6-naphthyridin-5(6H)-one|CS-0108565

Structure of 301666-81-9

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General Information

  • CAS No. 301666-81-9
  • Cat. No. CS-0108565
  • Purity ≥98%
  • MDL No. MFCD18073519
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇BrN₂O
  • Molecular Weight 227.06
  • Synonym(s) 3-bromo-7,8-dihydro-1,6-naphthyridin-5(6H)-one(WX142502)
  • SMILES O=C1C2=C(N=CC(Br)=C2)CCN1

Description

3-Bromo-7,8-dihydro-1,6-naphthyridin-5(6H)-one features a brominated dihydroquinoline core with a lactam functionality, enabling direct incorporation into Suzuki-Miyaura coupling reactions. The electron-deficient pyridine ring facilitates efficient transition metal catalysis, while the bench-stable heterocyclic scaffold supports downstream derivatization in medicinal chemistry and materials synthesis.

Application

3-Bromo-7,8-dihydro-1,6-naphthyridin-5(6H)-one serves as a versatile heterocyclic building block for medicinal chemistry and materials synthesis. The bromine substituent enables palladium-catalyzed cross-coupling reactions, while the dihydro-1,6-naphthyridinone core provides a rigid, electron-deficient scaffold suitable for bioactive molecule design. Bench-stable and compatible with standard purification methods, it facilitates efficient access to functionalized naphthyridine derivatives in multi-step synthetic sequences.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   41.99
  • LogP   1.13
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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