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Structure of 114897-91-5
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2-(4-Bromo-2-fluorophenyl)acetonitrile features a strategically positioned nitrile group flanked by bromine and fluorine substituents, enabling direct incorporation into cross-coupling cascades. This electron-deficient aryl acetonitrile delivers high functional group tolerance and stability under standard reaction conditions, serving as a key intermediate in the synthesis of bioactive heterocycles and pharmaceutical scaffolds.
2-(4-Bromo-2-fluorophenyl)acetonitrile serves as a versatile building block for constructing substituted aryl nitriles and heterocyclic scaffolds. Its bromine and fluorine substituents enable palladium-catalyzed cross-coupling reactions, while the nitrile group facilitates nucleophilic additions and cyclizations. The compound exhibits good bench stability and is readily purified by column chromatography, making it well-suited for iterative synthesis in medicinal chemistry and process development workflows.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: