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CS-W001157 4
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Fmoc-D-Hyp(tBu)-OH

  • CAS No. 464193-92-8

  • Cat. No. CS-0053412
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Fmoc-D-Hyp(tBu)-OH|CS-0053412

Structure of 464193-92-8

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General Information

  • CAS No. 464193-92-8
  • Cat. No. CS-0053412
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₄H₂₇NO₅
  • Molecular Weight 409.47
  • Synonym(s) Fmoc-O-tert-butyl-D-4-hydroxyproline
  • SMILES CC(C)(C)O[C@H]1C[C@H](N(C1)C(=O)OCC1C2=CC=CC=C2C2=C1C=CC=C2)C(O)=O

Description

Fmoc-D-Hyp(tBu)-OH is a bench-stable, moisture-tolerant amino acid derivative featuring a tert-butyl-protected hydroxyproline residue. This configuration enhances solubility and stability during solid-phase peptide synthesis, enabling efficient incorporation of D-Hyp into bioactive peptide sequences.

Application

Fmoc-D-Hyp(tBu)-OH serves as a key building block in the synthesis of peptide libraries and bioactive oligomers, leveraging the well-established stability and orthogonal protection of the Fmoc group. The D-Hyp(tBu) moiety provides a conformationally restricted proline analog with enhanced rigidity, facilitating the incorporation of type I collagen-mimetic structures. Its t-butyl-protected hydroxyl group enables selective derivatization and is compatible with standard solid-phase peptide synthesis protocols.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   76.07
  • LogP   4.2781
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   4

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