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CS-W001157 4
Total: USD 88.00

Fmoc-Hyp(tBu)-OH

  • CAS No. 122996-47-8

  • Cat. No. CS-W011680
  • Purity≥96%
  • MDL No.MFCD00151930

*For research and further manufacturing use only, not for direct human use.

Fmoc-Hyp(tBu)-OH|CS-W011680

Structure of 122996-47-8

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General Information

  • CAS No. 122996-47-8
  • Cat. No. CS-W011680
  • Purity ≥96%
  • MDL No. MFCD00151930
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₄H₂₇NO₅
  • Molecular Weight 409.47
  • Synonym(s) None
  • SMILES O=C(OCC1C2=C(C=CC=C2)C3=C1C=CC=C3)N4[C@@H](C[C@H](C4)OC(C)(C)C)C(O)=O

Description

Protein degrader builiding block Pomalidomide-PEG2-azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Automate your CRBN-PEG based PROTACs with Synple Automated Synthesis Platform (SYNPLE-SC002)

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   76.07
  • LogP   4.2781
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   4

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