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CS-W001157 4
Total: USD 88.00

1-Fluoro-4-methoxybenzene

  • CAS No. 459-60-9

  • Cat. No. CS-W016565
  • Purity≥97%
  • MDL No.MFCD00000348

*For research and further manufacturing use only, not for direct human use.

1-Fluoro-4-methoxybenzene|CS-W016565

Structure of 459-60-9

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General Information

  • CAS No. 459-60-9
  • Cat. No. CS-W016565
  • Purity ≥97%
  • MDL No. MFCD00000348
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇FO
  • Molecular Weight 126.13
  • Synonym(s) 4-Fluoroanisole
  • SMILES COC1=CC=C(F)C=C1

Description

1-Fluoro-4-methoxybenzene features a fluorine atom and a methoxy group positioned para to each other on a benzene ring, creating a highly electron-rich aromatic system with enhanced stability under standard conditions. This dual-functional substitution enables selective coupling reactions in synthetic chemistry, particularly in the construction of advanced pharmaceutical intermediates and functional materials where precise electronic tuning is required.

Application

1-Fluoro-4-methoxybenzene serves as a versatile aryl building block in medicinal chemistry and materials science, enabling efficient Suzuki-Miyaura and Buchwald-Hartwig couplings due to its orthogonal reactivity profile. The fluoro and methoxy groups provide complementary functional handles for sequential transformations, while the molecule exhibits excellent bench stability and ease of purification.

Synthesis

  • Route1
    • null|null
      104-94-9
    • ~84%
    • In-stock
      1-Fluoro-4-methoxybenzene|CS-W016565
      459-60-9

    References

    • Laali, Kenneth K.; Gettwert, Volker J. Journal of Fluorine Chemistry, 2001 , vol. 107, # 1 p. 31 - 34
  • Route2

    References

    • Belov, Pavel; Campanella, Veronica L.; Smith, Alison W.; Priefer, Ronny Tetrahedron Letters, 2011 , vol. 52, # 21 p. 2776 - 2779
  • Route3
    • (4-Methoxyphenyl)trimethylsilane|CS-0574046
      877-68-9
    • ~23%
    • In-stock
      1-Fluoro-4-methoxybenzene|CS-W016565
      459-60-9

    References

    • Meio, Giuseppe V. De; Pinhey, John T. Journal of the Chemical Society, Chemical Communications, 1990 , # 15 p. 1065 - 1066 Title/Abstract Full Text View citing articles Show Details De Meio; Morgan; Pinhey Tetrahedron, 1993 , vol. 49, # 36 p. 8129 - 8138

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02
Signal Word : Warning
UN#: 3271
Class : 3
Packing Group : Ⅲ
Hazard Statements : H226
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P370+P378-P501

Quality Control

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Computational Chemistry Data

  • TPSA   9.23
  • LogP   1.8343
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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