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CS-W001157 4
Total: USD 88.00

2,4-Difluoro-1-methoxybenzene

  • CAS No. 452-10-8

  • Cat. No. CS-W011011
  • Purity≥98%
  • MDL No.MFCD00010731

*For research and further manufacturing use only, not for direct human use.

2,4-Difluoro-1-methoxybenzene|CS-W011011

Structure of 452-10-8

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General Information

  • CAS No. 452-10-8
  • Cat. No. CS-W011011
  • Purity ≥98%
  • MDL No. MFCD00010731
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆F₂O
  • Molecular Weight 144.12
  • Synonym(s) 2,4-Difluoroanisole
  • SMILES COC1=C(F)C=C(F)C=C1

Synthesis

  • Route1

    References

    • F. HOFFMANN-LA ROCHE AG Patent: WO2004/101528 A2, 2004 ; Location in patent: Page 154 ;
  • Route2
    • In-stock
      2,4-Difluorophenol|CS-W013441
      367-27-1
    • null|null
      77-78-1
    • ~95%
    • In-stock
      2,4-Difluoro-1-methoxybenzene|CS-W011011
      452-10-8

    References

    • Chen, George T.; King, Michael; Gusovsky, Fabian; Creveling, Cyrus R.; Daly, John W.; et al. Journal of Medicinal Chemistry, 1993 , vol. 36, # 24 p. 3947 - 3955
  • Route3

    References

    • Syvret, Robert G.; Butt, Kathleen M.; Nguyen, Tung P.; Bulleck, Victoria L.; Rieth, Ryan D. Journal of Organic Chemistry, 2002 , vol. 67, # 13 p. 4487 - 4493

Safety Information

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GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H226-H315-H319-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   9.23
  • LogP   1.9734
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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