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CS-W001157 4
Total: USD 88.00

H-Glu-OtBu

  • CAS No. 45120-30-7

  • Cat. No. CS-W018940
  • Purity≥95%
  • MDL No.MFCD00038562

*For research and further manufacturing use only, not for direct human use.

H-Glu-OtBu|CS-W018940

Structure of 45120-30-7

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General Information

  • CAS No. 45120-30-7
  • Cat. No. CS-W018940
  • Purity ≥95%
  • MDL No. MFCD00038562
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₇NO₄
  • Molecular Weight 203.24
  • Synonym(s) None
  • SMILES N[C@@H](CCC(O)=O)C(OC(C)(C)C)=O

Description

H-Glu-OtBu is a protected glutamic acid derivative featuring a tert-butyl ester group, enabling stable incorporation into peptide synthesis workflows. This form facilitates efficient coupling reactions while minimizing side processes during chain elongation. The N-terminal amine remains free for selective functionalization, and the side-chain carboxylate is preserved in a labile, removable form.

Synthesis

  • Route1

    References

    • Eli Lilly and Company; COR Therapeutics Inc. Patent: US6291469 B1, 2001 ;
  • Route2

    References

    • Gengrinovitch, Stela; Izakovich, Esther Patent: US2007/72800 A1, 2007 ; Location in patent: Page/Page column 13 ;
  • Route3
    • 5-Benzyl 1-(tert-butyl) L-glutamate|CS-0488171
      80165-23-7
    • ~%
    • In-stock
      H-Glu-OtBu|CS-W018940
      45120-30-7

    References

    • Roeske,R. Journal of Organic Chemistry, 1963 , vol. 28, p. 1251 - 1253

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   89.62
  • LogP   0.5202
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   4

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