Z-Glu-OtBu

Name: Z-Glu-OtBu
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 5891-45-2
Cat. No. CS-W008549
Purity≥97%
MDL No.MFCD00077016

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Structure of 5891-45-2

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General Information

CAS No. 5891-45-2
Cat. No. CS-W008549
Purity ≥97%
MDL No. MFCD00077016
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₇H₂₃NO₆
Molecular Weight None
Synonym(s) None
SMILES O=C(O)CC[C@H](NC(OCC1=CC=CC=C1)=O)C(OC(C)(C)C)=O

Description

Z-Glu-OtBu features a protected glutamic acid side chain with a benzyl carbamate (Z) group at the α-amino terminus and tert-butyl ester functionality. This configuration enables stable incorporation into peptide sequences, facilitating efficient synthesis under standard conditions while offering orthogonal deprotection pathways for selective manipulation during complex assembly workflows.

Application

Z-Glu-OtBu serves as a robust amino acid building block for peptide synthesis, offering excellent bench stability and ease of purification. The benzyloxycarbonyl (Z) group provides reliable N-terminal protection, while the tert-butyl ester enables selective hydrolysis under mild acidic conditions. It functions effectively in standard coupling protocols, tolerates diverse reaction conditions, and facilitates efficient construction of complex peptide scaffolds.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 101.93
LogP 2.4879
H_Acceptors 5
H_Donors 2
Rotatable_Bonds 7

Other Classifications

Bioactive Molecules Peptides

Life Science Amino Acids and their Derivatives Glutamic acid and derivatives

Life Science Amino Acids and their Derivatives C-protected amino acid

Chemical Biology Peptide Chemistry Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Peptide Chemistry Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Amino Acid Derivatives

Biochemistry Biochemicals and Reagents Amino Acids C-ProtectedAmino Acids

Biochemistry Biochemicals and Reagents Amino Acids N-Protected Amino Acids

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Z-Glu-OtBu

CAS No. 5891-45-2

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