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CS-W001157 4
Total: USD 88.00

Boc-C16-COOH

  • CAS No. 843666-40-0

  • Cat. No. CS-0038601
  • Purity≥97%
  • MDL No.MFCD09991735

*For research and further manufacturing use only, not for direct human use.

Boc-C16-COOH|CS-0038601

Structure of 843666-40-0

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General Information

  • CAS No. 843666-40-0
  • Cat. No. CS-0038601
  • Purity ≥97%
  • MDL No. MFCD09991735
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₂H₄₂O₄
  • Molecular Weight 370.57
  • Synonym(s) None
  • SMILES CC(C)(OC(CCCCCCCCCCCCCCCCC(O)=O)=O)C

Description

Boc-C16-COOH is a long-chain fatty acid derivative featuring a tert-butoxycarbonyl-protected carboxylic acid group at the terminal end of a C16 alkyl chain. This amphiphilic structure enables facile incorporation into lipid-based systems, offering stability under standard bench conditions and compatibility with amide coupling protocols in peptide and conjugate synthesis.

Application

Boc-C16-COOH serves as a versatile C16 chain spacer with orthogonal protection, enabling efficient incorporation into peptide and non-peptide macrocycles. The tert-butoxycarbonyl (Boc) group provides stable protection under mild acidic conditions, while the terminal carboxylic acid facilitates coupling reactions with amines or alcohols. This compound exhibits excellent bench stability and simplifies purification in multi-step syntheses, making it ideal for constructing lipidated scaffolds and bioactive conjugates in medicinal chemistry workflows.

Synthesis

  • Route1

    References

    • Novo Nordisk A/S Patent: US2011/306551 A1, 2011 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   63.6
  • LogP   6.6543
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   17

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