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CS-W001157 4
Total: USD 88.00

H-Glu(OtBu)-OtBu hydrochloride

  • CAS No. 32677-01-3

  • Cat. No. CS-W008608
  • Purity≥96%
  • MDL No.MFCD00058003

*For research and further manufacturing use only, not for direct human use.

H-Glu(OtBu)-OtBu hydrochloride|CS-W008608

Structure of 32677-01-3

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General Information

  • CAS No. 32677-01-3
  • Cat. No. CS-W008608
  • Purity ≥96%
  • MDL No. MFCD00058003
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₂₆ClNO₄
  • Molecular Weight 295.80
  • Synonym(s) None
  • SMILES N[C@@H](CCC(OC(C)(C)C)=O)C(OC(C)(C)C)=O.[H]Cl

Description

H-Glu(OtBu)-OtBu (hydrochloride) is a protected glutamic acid derivative featuring two tert-butyl ester groups, providing enhanced stability and ease of handling. This bench-stable diester serves as a key building block in peptide synthesis, enabling efficient incorporation of glutamate residues under standard conditions. The hydrochloride salt form improves solubility and facilitates purification.

Synthesis

  • Route1
    • In-stock
      DL-Glutamic acid|CS-W022635
      617-65-2
    • null|null
      115-11-7
    • ~84%
    • In-stock
      H-Glu(OtBu)-OtBu hydrochloride|CS-W008608
      32677-01-3

    References

    • US2004/87813 A1, ;
  • Route2
    • null|null
      16881-41-7
    • ~%
    • In-stock
      H-Glu(OtBu)-OtBu hydrochloride|CS-W008608
      32677-01-3

    References

    • Recueil des Travaux Chimiques des Pays Bas, , vol. 102, # 11 p. 469 - 474
  • Route3
    • null|null
      540-88-5
    • In-stock
      (S)-2-aminopentanedioic acid hydrochloride|CS-W017035
      138-15-8
    • ~40%
    • In-stock
      H-Glu(OtBu)-OtBu hydrochloride|CS-W008608
      32677-01-3

    References

    • Journal of Medicinal Chemistry, , vol. 37, # 20 p. 3294 - 3302

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   78.62
  • LogP   2.1991
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   4

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