1-(tert-Butyl) 5-methyl L-glutamate hydrochloride

Name: 1-(tert-Butyl) 5-methyl L-glutamate hydrochloride
Brand: ChemScene
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CAS No. 34582-33-7
Cat. No. CS-0067114
Purity≥97%
MDL No.MFCD02094380

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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1-(tert-Butyl) 5-methyl L-glutamate hydrochloride|CS-0067114

Structure of 34582-33-7

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General Information

CAS No. 34582-33-7
Cat. No. CS-0067114
Purity ≥97%
MDL No. MFCD02094380
Storage 4°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₂₀ClNO₄
Molecular Weight 253.72
Synonym(s) None
SMILES N[C@@H](CCC(OC)=O)C(OC(C)(C)C)=O.[H]Cl

Description

This tert-butyl-protected L-glutamate derivative features a sterically hindered side chain and a methylated alpha position, enhancing stability and resistance to racemization. The hydrochloride salt form improves solubility in polar solvents and simplifies handling during peptide synthesis workflows.

Application

1-(tert-Butyl) 5-methyl L-glutamate hydrochloride serves as a stable, bench-ready building block for peptide and heterocyclic synthesis. Its tert-butyl ester group enables orthogonal protection during amine-directed transformations, while the methylated γ-carboxylate enhances metabolic stability. The hydrochloride salt improves solubility and handling, facilitating efficient coupling reactions and purification in standard synthetic workflows.

Synthesis

Route1
- 3077-51-8
- 115-11-7
- ~61%
- In-stock
  
  34582-33-7
References
- Baldwin, Jack E.; North, Michael; Flinn, Anthony; Moloney, Mark G. Tetrahedron, 1989 , vol. 45, # 5 p. 1453 - 1464
Route2
- In-stock
  
  56-86-0
- ~%
- In-stock
  
  34582-33-7
References
- Tetrahedron, , vol. 45, # 5 p. 1453 - 1464
Route3
- 186581-53-3
- 34897-61-5
- ~%
- In-stock
  
  34582-33-7
References
- Pharmazie, , vol. 43, # 2 p. 105 - 109

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 78.62
LogP 1.0304
H_Acceptors 5
H_Donors 1
Rotatable_Bonds 4

Other Classifications

Bioactive Molecules Peptides

Life Science Amino Acids and their Derivatives Glutamic acid and derivatives

Chemical Biology Peptide Chemistry Amino Acid Derivatives

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1-(tert-Butyl) 5-methyl L-glutamate hydrochloride

CAS No. 34582-33-7

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