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CS-W001157 4
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2-Fluoro-6-methylaniline

  • CAS No. 443-89-0

  • Cat. No. CS-W011172
  • Purity≥98%
  • MDL No.MFCD06658252

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-6-methylaniline|CS-W011172

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General Information

  • CAS No. 443-89-0
  • Cat. No. CS-W011172
  • Purity ≥98%
  • MDL No. MFCD06658252
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈FN
  • Molecular Weight 125.15
  • Synonym(s) Benzenamine, 2-fluoro-6-methyl-
  • SMILES FC1=C(N)C(=CC=C1)C

Description

2-Fluoro-6-methylaniline features a fluorinated aromatic ring paired with a methyl group at the para position, delivering enhanced electron density and improved metabolic stability. This configuration enables efficient incorporation into pharmaceutical intermediates and advanced materials. The compound exhibits excellent solubility in common organic solvents and maintains stability under standard bench conditions.

Application

2-Fluoro-6-methylaniline serves as a valuable building block for pharmaceutical and agrochemical synthesis, offering regioselective functionalization via its ortho-fluoro and para-methyl substituents. The fluorine atom enables bioisosteric replacement and enhances metabolic stability, while the aniline handle facilitates direct coupling reactions and electrophilic aromatic substitution. Bench-stable and compatible with standard purification methods, it functions reliably in multi-step syntheses involving amide formation, Suzuki coupling, or heterocycle construction.

Synthesis

  • Route1

    References

    • Loefgren et al. Acta Chemica Scandinavica (1947-1973), 1955 , vol. 9, p. 1079,1083

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H227-H302-H315-H318-H335
Precautionary Statements : P210-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P370+P378-P403-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   1.71632
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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