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CS-W001157 4
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2-Chloro-6-fluoroaniline

  • CAS No. 363-51-9

  • Cat. No. CS-W007751
  • Purity≥97%
  • MDL No.MFCD00040309

*For research and further manufacturing use only, not for direct human use.

2-Chloro-6-fluoroaniline|CS-W007751

Structure of 363-51-9

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General Information

  • CAS No. 363-51-9
  • Cat. No. CS-W007751
  • Purity ≥97%
  • MDL No. MFCD00040309
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅ClFN
  • Molecular Weight 145.56
  • Synonym(s) 2-Chloro-6-Fluoro Aniline
  • SMILES C1=C(C(=C(C=C1)Cl)N)F

Description

2-Chloro-6-fluoroaniline features a strategically positioned chlorine and fluorine substituent on the aromatic ring, delivering enhanced electronic modulation and metabolic stability. This electron-deficient aniline derivative integrates efficiently into pharmaceutical intermediates and agrochemical scaffolds, offering improved reactivity in coupling processes under standard conditions.

Application

2-Chloro-6-fluoroaniline serves as a valuable building block in medicinal chemistry and agrochemical synthesis, offering orthogonal reactivity for nucleophilic substitution and coupling reactions. Its halogenated aromatic scaffold enables efficient diversification via Pd-catalyzed cross-coupling, while the primary amine facilitates conjugation with electrophiles or incorporation into heterocyclic frameworks. Bench-stable and readily purified by recrystallization, it functions reliably in multi-step syntheses requiring selective functional group handling.

Synthesis

  • Route1

    References

    • Journal of Organic Chemistry, , vol. 20, p. 1577,1589
  • Route2
    • null|null
      90493-88-2
    • ~71%
    • In-stock
      2-Chloro-6-fluoroaniline|CS-W007751
      363-51-9

    References

    • Ayyangar, N. R.; Kalkote, U. R.; Nikrad, P. V. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 9 p. 872 - 877
  • Route3
    • null|null
      2369-21-3
    • ~%
    • In-stock
      2-Chloro-6-fluoroaniline|CS-W007751
      363-51-9

    References

    • Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 22, # 9 p. 872 - 877

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06,GHS08
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302-H312-H315-H319-H331-H373
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.0613
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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