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Structure of 4377-58-6
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5-Fluorothiophene-2-carboxylic acid integrates a fluorinated thiophene scaffold with a carboxylic acid functionality, offering enhanced electron-withdrawing character and improved metabolic stability. This structure facilitates direct coupling in synthetic routes to bioactive heterocycles and functional materials.
5-Fluorothiophene-2-carboxylic acid serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling direct incorporation of fluorinated thiophene motifs into bioactive molecules. Its carboxylic acid functionality facilitates straightforward amide, ester, and acyl chloride derivatization, while the fluorine substituent enhances metabolic stability and modulates electronic properties. The compound exhibits good bench stability and is compatible with standard coupling protocols, making it well-suited for modular synthesis workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: