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CS-W001157 4
Total: USD 88.00

5-Fluoroindoline

  • CAS No. 2343-22-8

  • Cat. No. CS-W013332
  • Purity≥97%
  • MDL No.MFCD00214461

*For research and further manufacturing use only, not for direct human use.

5-Fluoroindoline|CS-W013332

Structure of 2343-22-8

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General Information

  • CAS No. 2343-22-8
  • Cat. No. CS-W013332
  • Purity ≥97%
  • MDL No. MFCD00214461
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈FN
  • Molecular Weight 137.16
  • Synonym(s) 5-Fluoro-2,3-dihydro-indole
  • SMILES FC1=CC2=C(NCC2)C=C1

Description

5-Fluoroindoline serves as a valuable heterocyclic scaffold in medicinal chemistry, featuring a fluorinated indoline core that enhances metabolic stability and modulates electronic properties. This bench-stable compound integrates readily into diverse synthetic pathways, enabling efficient access to bioactive molecules through C–H functionalization and coupling reactions.

Application

5-Fluoroindoline serves as a valuable heterocyclic building block in medicinal chemistry, offering a fluorinated indoline core with enhanced metabolic stability and modulated electronic properties. Its bench-stable nature and compatibility with standard functional group manipulations facilitate efficient incorporation into bioactive scaffolds. The molecule enables direct C–H arylation, Suzuki coupling, and reductive amination protocols, supporting rapid diversification in lead optimization campaigns.

Synthesis

  • Route1

    References

    • Kulkarni, Aditya; Zhou, Weihong; Toeroek, Bela Organic Letters, 2011 , vol. 13, # 19 p. 5124 - 5127
  • Route2

    References

    • Zakrzewska; Kolehmainen; Osmialowski; Gawinecki Journal of Fluorine Chemistry, 2001 , vol. 111, # 1 p. 1 - 10
  • Route3

    References

    • Journal of Fluorine Chemistry, , vol. 111, # 1 p. 1 - 10

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   1.7937
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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