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CS-W001157 4
Total: USD 88.00

7-Fluoroindoline

  • CAS No. 769966-04-3

  • Cat. No. CS-0179590
  • Purity≥95%
  • MDL No.MFCD09041825

*For research and further manufacturing use only, not for direct human use.

7-Fluoroindoline|CS-0179590

Structure of 769966-04-3

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General Information

  • CAS No. 769966-04-3
  • Cat. No. CS-0179590
  • Purity ≥95%
  • MDL No. MFCD09041825
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈FN
  • Molecular Weight 137.15
  • Synonym(s) OTAVA-BB 1118853
  • SMILES FC1=CC=CC2=C1NCC2

Description

7-Fluoroindoline serves as a key heterocyclic scaffold in medicinal chemistry, featuring a fluorinated indoline core that enhances metabolic stability and modulates electronic properties. This bench-stable compound integrates readily into diverse synthetic routes, enabling efficient access to bioactive molecules through C–H functionalization and coupling reactions.

Application

7-Fluoroindoline serves as a valuable building block in medicinal chemistry, offering a fluorinated heterocyclic scaffold with enhanced metabolic stability and modulated electronic properties. Its structure facilitates diverse functionalizations at the indoline core, enabling efficient access to biologically active compounds through standard coupling and cyclization protocols. The fluorine substituent enhances lipophilicity and membrane permeability, making it particularly useful in drug discovery campaigns targeting CNS disorders and kinase inhibitors. Bench-stable and compatible with common purification methods, it functions reliably in multistep syntheses.

Synthesis

  • Route1

    References

    • Takeda Pharmaceutical Company Limited Patent: EP2399914 A1, 2011 ; Location in patent: Page/Page column 97 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340

Quality Control

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   1.7937
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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