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CS-W001157 4
Total: USD 88.00

7-Fluoro-1H-indole

  • CAS No. 387-44-0

  • Cat. No. CS-W007613
  • Purity≥98%
  • MDL No.MFCD01074502

*For research and further manufacturing use only, not for direct human use.

7-Fluoro-1H-indole|CS-W007613

Structure of 387-44-0

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General Information

  • CAS No. 387-44-0
  • Cat. No. CS-W007613
  • Purity ≥98%
  • MDL No. MFCD01074502
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆FN
  • Molecular Weight 135.14
  • Synonym(s) None
  • SMILES FC1=CC=CC2=C1NC=C2

Description

7-Fluoro-1H-indole delivers a fluorinated indole scaffold with enhanced electron-withdrawing character due to the para-fluorine substitution. This bench-stable heterocycle integrates readily into medicinal chemistry campaigns, serving as a key building block for bioactive molecules in kinase inhibitors and CNS-targeted therapeutics.

Application

7-Fluoro-1H-indole serves as a valuable building block in medicinal chemistry, enabling direct incorporation of a fluorinated aromatic ring into bioactive molecules. Its bench-stable nature and compatibility with standard coupling reactions facilitate efficient synthesis of indole-based scaffolds. The fluoro substituent enhances metabolic stability and modulates electronic properties, making it particularly useful for optimizing pharmacokinetic profiles in API development.

Synthesis

  • Route1

    References

    • Schlosser, Manfred; Ginanneschi, Assunta; Leroux, Frederic European Journal of Organic Chemistry, 2006 , # 13 p. 2956 - 2969
  • Route2
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      348-54-9
    • null|null
      75-34-3
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      107-14-2
    • null|null
      107-06-2
    • ~%
    • In-stock
      7-Fluoro-1H-indole|CS-W007613
      387-44-0

    References

    • ELI LILLY AND COMPANY LIMITED Patent: EP897921 A1, 1999 ;
  • Route3
    • null|null
      908600-90-8
    • ~37%
    • In-stock
      7-Fluoro-1H-indole|CS-W007613
      387-44-0

    References

    • Schlosser, Manfred; Ginanneschi, Assunta; Leroux, Frederic European Journal of Organic Chemistry, 2006 , # 13 p. 2956 - 2969

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   15.79
  • LogP   2.307
  • H_Acceptors   0
  • H_Donors   1
  • Rotatable_Bonds   0

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