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CS-W001157 4
Total: USD 88.00

6,7-Difluoro-1H-indole

  • CAS No. 271780-84-8

  • Cat. No. CS-0311903
  • Purity95+%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6,7-Difluoro-1H-indole|CS-0311903

Structure of 271780-84-8

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General Information

  • CAS No. 271780-84-8
  • Cat. No. CS-0311903
  • Purity 95+%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅F₂N
  • Molecular Weight 153.13
  • Synonym(s) 1H-Indole,6,7-difluoro-(9CI)
  • SMILES FC1=C(F)C=CC2=C1NC=C2

Description

6,7-Difluoro-1H-indole features a highly electron-deficient indole core due to the dual fluorine substituents at the 6 and 7 positions. This configuration enhances stability and directs electrophilic substitution selectively to the 3- and 4-positions. The molecule integrates readily into bioactive scaffolds and serves as a key building block in medicinal chemistry for modulating metabolic stability and membrane permeability.

Application

6,7-Difluoro-1H-indole serves as a valuable building block for the synthesis of fluorinated heterocycles and bioactive molecules. Its electron-deficient aromatic core enables efficient transition-metal-catalyzed couplings and direct C–H functionalization. The difluoro substitution pattern enhances metabolic stability and modulates electronic properties, making it particularly useful in medicinal chemistry applications requiring improved pharmacokinetic profiles.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   15.79
  • LogP   2.4461
  • H_Acceptors   0
  • H_Donors   1
  • Rotatable_Bonds   0

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