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Structure of 4319-87-3
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5-Bromo-4-methoxy-6-methylpyrimidine features a pyrimidine core functionalized with bromo, methoxy, and methyl groups at strategic positions. This electron-deficient heterocycle serves as a key scaffold for medicinal chemistry applications, offering enhanced metabolic stability and tailored reactivity in cross-coupling transformations. The substitution pattern enables precise tuning of electronic and steric properties for drug discovery workflows.
5-Bromo-4-methoxy-6-methylpyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. Its well-defined regiochemistry and stability under standard reaction conditions facilitate reliable synthesis of substituted pyrimidines. The bromo group provides a high-yielding handle for Suzuki, Stille, or Negishi coupling, while the methoxy and methyl substituents offer predictable electronic modulation and orthogonal reactivity. This compound functions effectively in the construction of bioactive heterocyclic scaffolds and is compatible with common purification methods.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: