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CS-W001157 4
Total: USD 88.00

4-Bromo-2-cyclopropylpyridine

  • CAS No. 1086381-28-3

  • Cat. No. CS-0155391
  • Purity≥97%
  • MDL No.MFCD11223210

*For research and further manufacturing use only, not for direct human use.

4-Bromo-2-cyclopropylpyridine|CS-0155391

Structure of 1086381-28-3

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General Information

  • CAS No. 1086381-28-3
  • Cat. No. CS-0155391
  • Purity ≥97%
  • MDL No. MFCD11223210
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈BrN
  • Molecular Weight 198.06
  • Synonym(s) None
  • SMILES C1CC1C2=NC=CC(=C2)Br

Description

4-Bromo-2-cyclopropylpyridine is a bench-stable heterocyclic building block featuring a bromine atom at the 4-position and a cyclopropyl group at the 2-position of the pyridine ring. This combination delivers enhanced electronic modulation and steric profile, enabling efficient coupling in cross-coupling reactions. The molecule integrates readily into complex scaffolds for medicinal chemistry and materials science applications.

Application

4-Bromo-2-cyclopropylpyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its well-established halogen reactivity. The cyclopropyl group imparts favorable steric and electronic properties, enhancing metabolic stability in target molecules. Bench-stable and readily purified, it functions effectively in standard Suzuki, Stille, and Negishi couplings, facilitating efficient assembly of complex heterocyclic scaffolds relevant to pharmaceutical discovery.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.7215
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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