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Structure of 425394-89-4
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4,6-Dichloropyrimidin-5-ol is a bench-stable, moisture-tolerant heterocyclic building block featuring two chlorine substituents at the 4- and 6-positions flanking a hydroxyl group at C5. This arrangement enables efficient coupling reactions in medicinal chemistry, particularly for constructing kinase inhibitors and nucleoside analogs. The electron-deficient pyrimidine ring facilitates nucleophilic substitution under mild conditions.
4,6-Dichloropyrimidin-5-ol serves as a versatile building block in medicinal chemistry and heterocyclic synthesis. Its dual chlorine substituents enable efficient nucleophilic substitution reactions, facilitating the installation of diverse amine, thiol, or oxygen-based side chains. The pyrimidine scaffold provides structural rigidity and hydrogen-bonding capability, enhancing target affinity in bioactive molecules. Bench-stable and readily purified by recrystallization, it functions as a key intermediate in the construction of kinase inhibitors and antiviral agents.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: