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CS-W001157 4
Total: USD 88.00

2-Fluoro-6-methylpyridine

  • CAS No. 407-22-7

  • Cat. No. CS-W013665
  • Purity≥98%
  • MDL No.MFCD00041226

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-6-methylpyridine|CS-W013665

Structure of 407-22-7

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General Information

  • CAS No. 407-22-7
  • Cat. No. CS-W013665
  • Purity ≥98%
  • MDL No. MFCD00041226
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆FN
  • Molecular Weight 111.12
  • Synonym(s) 6-Fluoro-2-picoline
  • SMILES C1=CC=C(N=C1C)F

Description

2-Fluoro-6-methylpyridine serves as a key heterocyclic building block in medicinal chemistry, featuring a fluorinated ring and a methyl substituent that enhance metabolic stability and modulate electronic properties. This bench-stable, moisture-tolerant scaffold integrates readily into diverse synthetic pathways, enabling efficient access to bioactive compounds with tailored pharmacokinetic profiles.

Application

2-Fluoro-6-methylpyridine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the pyridine ring via palladium-catalyzed cross-coupling. Its fluorine and methyl groups provide orthogonal reactivity and enhanced metabolic stability, while its bench-stable nature facilitates handling and purification. Functions as a key scaffold for kinase inhibitors and CNS-targeted therapeutics.

Synthesis

  • Route1

    References

    • Yoneda; Fukuhara Tetrahedron, 1996 , vol. 52, # 1 p. 23 - 36
  • Route2

    References

    • Uchibori, Yukitaka; Umeno, Masayuki; Yoshioka, Hirosuke Heterocycles, 1992 , vol. 34, # 8 p. 1507 - 1510

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H227-H315-H319-H335
Precautionary Statements : P210-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P403-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   1.52912
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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