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CS-W001157 4
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5-Aminopyrazine-2-carboxylic acid

  • CAS No. 40155-43-9

  • Cat. No. CS-W019175
  • Purity≥97%
  • MDL No.MFCD07371664

*For research and further manufacturing use only, not for direct human use.

5-Aminopyrazine-2-carboxylic acid|CS-W019175

Structure of 40155-43-9

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General Information

  • CAS No. 40155-43-9
  • Cat. No. CS-W019175
  • Purity ≥97%
  • MDL No. MFCD07371664
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅N₃O₂
  • Molecular Weight 139.11
  • Synonym(s) 5-amino-2-pyrazinecarboxylic acid
  • SMILES NC1=NC=C(N=C1)C(=O)O

Description

5-Aminopyrazine-2-carboxylic acid features a pyrazine core with complementary amine and carboxylic acid functionalities, enabling direct incorporation into heterocyclic scaffolds. This bifunctional motif supports conjugation in medicinal chemistry and materials synthesis, offering enhanced solubility and directional reactivity under standard conditions.

Application

5-Aminopyrazine-2-carboxylic acid serves as a versatile scaffold for constructing bioactive heterocycles, enabling direct incorporation into pharmaceutical intermediates via amide coupling or electrophilic substitution. Its dual functional groups—amine and carboxylic acid—offer orthogonal reactivity for modular synthesis, while its bench-stable crystalline form facilitates handling and purification in medicinal chemistry workflows.

Synthesis

  • Route1

    References

    • Ellingson; Henry Journal of the American Chemical Society, 1949 , vol. 71, p. 2798

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   89.1
  • LogP   -0.243
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   1

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