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CS-W001157 4
Total: USD 88.00

6-Aminopyrazine-2-carboxylic acid

  • CAS No. 61442-38-4

  • Cat. No. CS-W003739
  • Purity≥95%
  • MDL No.MFCD10697804

*For research and further manufacturing use only, not for direct human use.

6-Aminopyrazine-2-carboxylic acid|CS-W003739

Structure of 61442-38-4

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General Information

  • CAS No. 61442-38-4
  • Cat. No. CS-W003739
  • Purity ≥95%
  • MDL No. MFCD10697804
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅N₃O₂
  • Molecular Weight 139.11
  • Synonym(s) Pyrazinecarboxylic acid, 6-amino- (9CI)
  • SMILES Nc1cncc(n1)C(=O)O

Description

6-Aminopyrazine-2-carboxylic acid features a fused pyrazine core functionalized with amino and carboxylic acid groups at opposite positions, enabling dual-site conjugation. This electron-deficient heterocycle integrates readily into pharmaceutical scaffolds and serves as a key intermediate in the synthesis of bioactive molecules.

Application

6-Aminopyrazine-2-carboxylic acid serves as a versatile heterocyclic building block for medicinal chemistry and catalytic synthesis. Its dual functionality—amine and carboxylic acid groups—enables straightforward derivatization via amidation, esterification, or coupling reactions. The pyrazine core provides enhanced metabolic stability and favorable electronic properties in bioactive scaffolds. Bench-stable and readily purified by recrystallization, it functions effectively in standard peptide coupling and transition-metal-catalyzed transformations.

Synthesis

  • Route1
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    • In-stock
      6-Aminopyrazine-2-carboxylic acid|CS-W003739
      61442-38-4

    References

    • Journal of Organic Chemistry, , vol. 24, p. 345,348
  • Route2
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      5594-16-1
    • ~%
    • In-stock
      6-Aminopyrazine-2-carboxylic acid|CS-W003739
      61442-38-4

    References

    • Journal of Organic Chemistry, , vol. 24, p. 345,348

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   89.1
  • LogP   -0.243
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   1

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