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Methyl 4-aminothiophene-3-carboxylate hydrochloride

  • CAS No. 39978-14-8

  • Cat. No. CS-W015760
  • Purity≥95%
  • MDL No.MFCD00068149

*For research and further manufacturing use only, not for direct human use.

Methyl 4-aminothiophene-3-carboxylate hydrochloride|CS-W015760

Structure of 39978-14-8

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General Information

  • CAS No. 39978-14-8
  • Cat. No. CS-W015760
  • Purity ≥95%
  • MDL No. MFCD00068149
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈ClNO₂S
  • Molecular Weight 193.65
  • Synonym(s) methyl4-aminothiophene-3-carboxylateHCl
  • SMILES O=C(C1=CSC=C1N)OC.[H]Cl

Description

PEG13 is a polymer consisting of ethylene glycol subunits with two terminal hydroxyl groups. The hydroxyl groups can undergo reactions to further derivatize the compound. The hydrophilic properties of the PEG linker increases the water solubility properties of attached compounds in aqueous media.

Application

Methyl 4-aminothiophene-3-carboxylate hydrochloride serves as a versatile building block in heterocyclic synthesis, enabling efficient access to bioactive thiophene scaffolds. The amine and ester functionalities offer orthogonal reactivity for derivatization, while the hydrochloride salt enhances bench stability and solubility. This compound facilitates straightforward functional group interconversions and participates reliably in coupling reactions, making it well-suited for medicinal chemistry and process development workflows.

Synthesis

  • Route1

    References

    • Barker, John M.; Huddleston, Patrick R.; Wood, Michael L. Synthetic Communications, 2002 , vol. 32, # 16 p. 2565 - 2568
  • Route2
    • null|null
      58230-46-9
    • ~90%
    • In-stock
      Methyl 4-aminothiophene-3-carboxylate hydrochloride|CS-W015760
      39978-14-8

    References

    • AVANIR PHARMACEUTICALS Patent: WO2006/102191 A1, 2006 ; Location in patent: Page/Page column 56; 88-89 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   52.32
  • LogP   1.5387
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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