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CS-W001157 4
Total: USD 88.00

Forskolin

  • CAS No. 66575-29-9

  • Cat. No. CS-1454
  • Purity≥97%
  • MDL No.MFCD00082317

*For research and further manufacturing use only, not for direct human use.

Forskolin|CS-1454

Structure of 66575-29-9

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General Information

  • CAS No. 66575-29-9
  • Cat. No. CS-1454
  • Purity ≥97%
  • MDL No. MFCD00082317
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₂H₃₄O₇
  • Molecular Weight 410.50
  • Synonym(s) Coleonol; Colforsin; HL 362
  • SMILES O=C1[C@@]2(O)[C@]([C@@H](OC(C)=O)[C@@H](O)[C@@]3([H])C(C)(C)CC[C@H](O)[C@@]32C)(C)O[C@@](C)(C=C)C1

Description

Forskolin is a labdane-type diterpene isolated from Coleus forskohlii, renowned for its potent activation of adenylate cyclase. This catalytic activity elevates intracellular cAMP levels, enabling precise modulation of downstream signaling pathways. The compound exhibits robust stability under standard bench conditions and integrates readily into cellular assays probing cyclic nucleotide-dependent processes.

Application

Forskolin serves as a potent, naturally derived activator of adenylate cyclase, enabling sustained elevation of intracellular cAMP levels. Its labdane diterpene scaffold exhibits high stability under standard laboratory conditions and demonstrates consistent bioactivity in cellular signaling studies. The molecule's functionalized lactone and hydroxyl groups allow for targeted derivatization while maintaining core pharmacophore integrity, making it a valuable tool in biochemical assay development and signal transduction research.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H312-H317
Precautionary Statements : P261-P272-P280-P302+P352-P312-P333+P313-P363-P501

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Computational Chemistry Data

  • TPSA   113.29
  • LogP   1.5199
  • H_Acceptors   7
  • H_Donors   3
  • Rotatable_Bonds   2

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