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Methyl 3-aminofuran-2-carboxylate

  • CAS No. 956034-04-1

  • Cat. No. CS-D0284
  • Purity≥95%
  • MDL No.MFCD09953568

*For research and further manufacturing use only, not for direct human use.

Methyl 3-aminofuran-2-carboxylate|CS-D0284

Structure of 956034-04-1

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General Information

  • CAS No. 956034-04-1
  • Cat. No. CS-D0284
  • Purity ≥95%
  • MDL No. MFCD09953568
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇NO₃
  • Molecular Weight 141.12
  • Synonym(s) Methyl 3-aminofuran-4-carboxylate
  • SMILES O=C(C1=C(N)C=CO1)OC

Description

Methyl 3-aminofuran-2-carboxylate is a bench-stable, moisture-tolerant heterocyclic building block featuring a fused furan ring with strategically positioned amino and ester functionalities. This compound integrates readily into synthetic sequences requiring electron-rich aromatic systems, enabling efficient access to complex pharmaceutical intermediates through palladium-catalyzed coupling and functional group interconversions.

Application

Methyl 3-aminofuran-2-carboxylate serves as a versatile building block in heterocyclic synthesis, enabling efficient access to furan-based scaffolds prevalent in medicinal chemistry. The amine group facilitates direct derivatization via acylation, alkylation, or coupling reactions, while the ester functionality supports selective reduction or nucleophilic substitution. Its bench-stable nature and compatibility with standard reaction conditions make it well-suited for iterative synthesis workflows.

Synthesis

  • Route1

    References

    • BIOCRYST PHARMACEUTICALS, INC.; BABU, Yarlagadda, S.; KOTIAN, Pravin, L. Patent: WO2011/79230 A2, 2011 ; Location in patent: Page/Page column 56; 57 ; WO 2011/079230 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   65.46
  • LogP   0.6484
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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