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CS-W001157 4
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2-(4-Fluorophenyl)-2-hydroxyacetic acid

  • CAS No. 395-33-5

  • Cat. No. CS-0059151
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(4-Fluorophenyl)-2-hydroxyacetic acid|CS-0059151

Structure of 395-33-5

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General Information

  • CAS No. 395-33-5
  • Cat. No. CS-0059151
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇FO₃
  • Molecular Weight 170.14
  • Synonym(s) p-Fluoromandelic acid
  • SMILES O=C(O)C(O)C1=CC=C(F)C=C1

Description

This hydroxyacid features a 4-fluorophenyl group attached to a chiral α-hydroxyacetic backbone, combining enhanced metabolic stability with favorable solubility. The para-fluoro substitution imparts electron-withdrawing character, modulating reactivity in downstream transformations. This bench-stable compound integrates readily into synthetic sequences requiring polar, aromatic functionalities under standard conditions.

Application

2-(4-Fluorophenyl)-2-hydroxyacetic acid serves as a versatile building block for synthesizing bioactive heterocycles and pharmaceutical intermediates. Its ortho-hydroxyacid functionality enables facile cyclization reactions, while the fluorinated aromatic ring enhances metabolic stability and modulates electronic properties. The compound exhibits good bench stability and compatibility with standard protecting group strategies, facilitating downstream functionalization in medicinal chemistry campaigns.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P302+P352-P304+P340

Quality Control

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Computational Chemistry Data

  • TPSA   57.53
  • LogP   0.9437
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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