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Methyl 2-(4-fluorophenyl)-2-hydroxyacetate

  • CAS No. 127709-19-7

  • Cat. No. CS-0216337
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Methyl 2-(4-fluorophenyl)-2-hydroxyacetate|CS-0216337

Structure of 127709-19-7

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General Information

  • CAS No. 127709-19-7
  • Cat. No. CS-0216337
  • Purity ≥95%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉FO₃
  • Molecular Weight 184.16
  • Synonym(s) Methyl (4-fluorophenyl)(hydroxy)acetate
  • SMILES COC(=O)C(C1=CC=C(C=C1)F)O

Description

Methyl 2-(4-fluorophenyl)-2-hydroxyacetate features a benzylic hydroxyl group flanked by a fluorinated phenyl ring and an ester moiety, offering enhanced stability and controlled reactivity. This configuration enables efficient integration into complex synthetic sequences, particularly in the construction of chiral intermediates and bioactive scaffolds under standard bench conditions.

Application

Methyl 2-(4-fluorophenyl)-2-hydroxyacetate serves as a versatile building block for the synthesis of chiral arylglycolic acid derivatives and pharmaceutically relevant heterocycles. The α-hydroxy ester functionality enables facile oxidation to the corresponding carboxylic acid or conversion to enol ethers, while the para-fluorophenyl group provides orthogonal reactivity for subsequent functionalization. Bench-stable and amenable to standard purification methods, it functions reliably in multistep syntheses requiring controlled stereochemistry and functional group compatibility.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   1.0321
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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