(R)-1-Boc-2-ethyl-piperazine

Name: (R)-1-Boc-2-ethyl-piperazine
Brand: ChemScene
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CAS No. 393781-70-9
Cat. No. CS-W019753
Purity≥97%
MDL No.MFCD03411920

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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General Information

CAS No. 393781-70-9
Cat. No. CS-W019753
Purity ≥97%
MDL No. MFCD03411920
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₂₂N₂O₂
Molecular Weight 214.30
Synonym(s) (R)-1-Boc-2-ethylPiperazine
SMILES O=C(OC(C)(C)C)N1[C@H](CC)CNCC1

Description

(R)-1-Boc-2-ethyl-piperazine is a chiral piperazine derivative featuring a Boc-protected amine and an ethyl substituent at the 2-position. This bench-stable, moisture-tolerant scaffold integrates readily into asymmetric synthesis workflows, enabling efficient access to bioactive alkaloids and pharmaceutical intermediates through selective deprotection and coupling reactions.

Application

(R)-1-Boc-2-ethyl-piperazine serves as a stereochemically defined building block for the synthesis of bioactive piperazine-based scaffolds. The Boc group provides orthogonal protection, enabling selective deprotection under mild acidic conditions. Its ethyl substituent enhances lipophilicity and modulates solubility, while the piperazine core facilitates diverse functionalization—ideal for medicinal chemistry campaigns requiring precise stereocontrol and robust handling during multi-step syntheses.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 41.57
LogP 1.6053
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aliphatic heterocycle compounds Piperazine compounds

Key Words

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(R)-1-Boc-2-ethyl-piperazine

CAS No. 393781-70-9

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