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CS-W001157 4
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(S)-1-Boc-2-ethyl-piperazine

  • CAS No. 325145-35-5

  • Cat. No. CS-D0655
  • Purity≥96%
  • MDL No.MFCD07772100

*For research and further manufacturing use only, not for direct human use.

(S)-1-Boc-2-ethyl-piperazine|CS-D0655

Structure of 325145-35-5

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General Information

  • CAS No. 325145-35-5
  • Cat. No. CS-D0655
  • Purity ≥96%
  • MDL No. MFCD07772100
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₂₂N₂O₂
  • Molecular Weight 214.30
  • Synonym(s) tert-Butyl (2S)-2-ethylpiperazine-1-carboxylate
  • SMILES O=C(OC(C)(C)C)N1[C@@H](CC)CNCC1

Description

(S)-1-Boc-2-ethyl-piperazine is a chiral piperazine derivative featuring a Boc-protected amine and an ethyl substituent at the 2-position. This bench-stable intermediate enables stereoselective synthesis of bioactive molecules, particularly in medicinal chemistry applications where controlled nitrogen functionality and defined stereochemistry are critical.

Application

(S)-1-Boc-2-ethyl-piperazine serves as a versatile chiral building block in medicinal chemistry, enabling the construction of piperazine-based scaffolds with defined stereochemistry. The Boc group provides stability and ease of deprotection under mild acidic conditions, while the ethyl substituent enhances solubility and modulates electronic properties. This derivative facilitates efficient functionalization in standard coupling reactions and supports orthogonal protection strategies in complex molecule synthesis.

Synthesis

  • Route1
    • 1,1-Dimethylethyl (2S)-2-ethyl-4-(phenylmethyl)-1-piperazinecarboxylate|CS-0764852
      502482-44-2
    • ~%
    • In-stock
      (S)-1-Boc-2-ethyl-piperazine|CS-D0655
      325145-35-5

    References

    • Journal of Medicinal Chemistry, , vol. 39, # 7 p. 1345 - 1348
  • Route2

    References

    • Journal of Medicinal Chemistry, , vol. 39, # 7 p. 1345 - 1348
  • Route3

    References

    • Journal of Medicinal Chemistry, , vol. 39, # 7 p. 1345 - 1348

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   41.57
  • LogP   1.6053
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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