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CS-W001157 4
Total: USD 88.00

4-Bromo-3-fluoropyridine

  • CAS No. 2546-52-3

  • Cat. No. CS-0053855
  • Purity≥97%
  • MDL No.MFCD04113266

*For research and further manufacturing use only, not for direct human use.

4-Bromo-3-fluoropyridine|CS-0053855

Structure of 2546-52-3

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General Information

  • CAS No. 2546-52-3
  • Cat. No. CS-0053855
  • Purity ≥97%
  • MDL No. MFCD04113266
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃BrFN
  • Molecular Weight 175.99
  • Synonym(s) Pyridine, 4-bromo-3-fluoro-
  • SMILES BrC1=C(C=NC=C1)F

Description

4-Bromo-3-fluoropyridine is a halogenated pyridine derivative featuring complementary electrophilic and nucleophilic sites. This electron-deficient heterocycle enables selective cross-coupling reactions under mild conditions, serving as a key building block in medicinal chemistry and agrochemical synthesis.

Application

4-Bromo-3-fluoropyridine serves as a versatile building block in medicinal chemistry and cross-coupling synthesis, enabling the construction of biologically relevant heterocyclic scaffolds. Its orthogonal halogenation pattern facilitates sequential metal-catalyzed transformations, with the bromo group typically undergoing palladium-catalyzed coupling while the fluoro substituent remains inert under standard conditions. The compound exhibits good bench stability, ease of purification, and compatibility with diverse reaction conditions, making it a reliable reagent for targeted molecular elaboration in drug discovery programs.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   1.9832
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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