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CS-W001157 4
Total: USD 88.00

(R)-1-N-Boc-piperazine-3-carboxylic acid methyl ester

  • CAS No. 438631-77-7

  • Cat. No. CS-D0195
  • Purity≥97%
  • MDL No.MFCD04115325

*For research and further manufacturing use only, not for direct human use.

(R)-1-N-Boc-piperazine-3-carboxylic acid methyl ester|CS-D0195

Structure of 438631-77-7

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General Information

  • CAS No. 438631-77-7
  • Cat. No. CS-D0195
  • Purity ≥97%
  • MDL No. MFCD04115325
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₂₀N₂O₄
  • Molecular Weight 244.29
  • Synonym(s) (R)-4-N-Boc-piperazine-2-carboxylic acid methyl ester
  • SMILES O=C(OC(C)(C)C)N1C[C@@H](NCC1)C(OC)=O

Description

This chiral building block features a Boc-protected piperazine core with a methyl ester-functionalized carboxylic acid, enabling direct incorporation into peptide and macrocyclic scaffolds. The (R)-stereochemistry ensures high diastereoselectivity in downstream conjugations, while the bench-stable, moisture-tolerant nature simplifies handling under standard conditions.

Application

(R)-1-N-Boc-piperazine-3-carboxylic acid methyl ester serves as a versatile chiral building block for the synthesis of piperazinyl-containing scaffolds. Its Boc-protected amine and ester functionalities enable sequential functionalization, facilitating coupling reactions and selective deprotection. The molecule exhibits excellent bench stability and simplifies purification in multi-step syntheses, making it well-suited for medicinal chemistry campaigns targeting CNS agents and kinase inhibitors.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   67.87
  • LogP   0.3683
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   1

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