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CS-W001157 4
Total: USD 88.00

2-(2,4-Difluorophenyl)-5-(trifluoromethyl)pyridine

  • CAS No. 387827-64-7

  • Cat. No. CS-0086391
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(2,4-Difluorophenyl)-5-(trifluoromethyl)pyridine|CS-0086391

Structure of 387827-64-7

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General Information

  • CAS No. 387827-64-7
  • Cat. No. CS-0086391
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₆F₅N
  • Molecular Weight 259.17
  • Synonym(s) None
  • SMILES FC(C=C1F)=CC=C1C(C=C2)=NC=C2C(F)(F)F

Application

2-(2,4-Difluorophenyl)-5-(trifluoromethyl)pyridine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard cross-coupling and functional group transformation protocols. Its structural motif combines electron-deficient aromatic systems with orthogonal fluorinated substituents, offering enhanced metabolic stability and favorable binding interactions. The compound exhibits excellent bench stability and facilitates efficient purification, making it well-suited for iterative synthesis campaigns in API development.

Synthesis

  • Route1

    References

    • Hanss, David; Freys, Jonathan C.; Bernardinelli, Gerald; Wenger, Oliver S. European Journal of Inorganic Chemistry, 2009 , # 32 p. 4850 - 4859

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   4.0456
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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