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CS-W001157 4
Total: USD 88.00

2-(2,4-Difluorophenyl)-5-fluoropyridine

  • CAS No. 1426047-01-9

  • Cat. No. CS-0098986
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(2,4-Difluorophenyl)-5-fluoropyridine|CS-0098986

Structure of 1426047-01-9

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General Information

  • CAS No. 1426047-01-9
  • Cat. No. CS-0098986
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₆F₃N
  • Molecular Weight 209.17
  • Synonym(s) None
  • SMILES FC1=CN=C(C=C1)C2=CC=C(C=C2F)F

Description

2-(2,4-Difluorophenyl)-5-fluoropyridine features a fluorinated pyridine core paired with a 2,4-difluorophenyl substituent, delivering enhanced electron deficiency and improved metabolic stability. This scaffold integrates readily into pharmaceutical intermediates, enabling efficient coupling in cross-coupling reactions under standard conditions. The molecule exhibits favorable solubility and bench-stable handling characteristics, making it well-suited for process development workflows.

Application

2-(2,4-Difluorophenyl)-5-fluoropyridine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through palladium-catalyzed cross-coupling reactions. Its fluorinated arylpyridine framework offers enhanced metabolic stability and favorable pharmacokinetic properties, while the orthogonal reactivity of its halogen substituents facilitates sequential functionalization. The compound exhibits excellent bench stability and is compatible with standard synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   3.1659
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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