2-(2,4-Difluorophenyl)-5-fluoropyridine

Name: 2-(2,4-Difluorophenyl)-5-fluoropyridine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1426047-01-9
Cat. No. CS-0098986
Purity≥98%
MDL No.None

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HazMat Fee

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Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

2-(2,4-Difluorophenyl)-5-fluoropyridine|CS-0098986

Structure of 1426047-01-9

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Description

2-(2,4-Difluorophenyl)-5-fluoropyridine features a fluorinated pyridine core paired with a 2,4-difluorophenyl substituent, delivering enhanced electron deficiency and improved metabolic stability. This scaffold integrates readily into pharmaceutical intermediates, enabling efficient coupling in cross-coupling reactions under standard conditions. The molecule exhibits favorable solubility and bench-stable handling characteristics, making it well-suited for process development workflows.

Application

2-(2,4-Difluorophenyl)-5-fluoropyridine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through palladium-catalyzed cross-coupling reactions. Its fluorinated arylpyridine framework offers enhanced metabolic stability and favorable pharmacokinetic properties, while the orthogonal reactivity of its halogen substituents facilitates sequential functionalization. The compound exhibits excellent bench stability and is compatible with standard synthetic workflows.

General Information

CAS No. 1426047-01-9
Cat. No. CS-0098986
Purity ≥98%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₆F₃N
Molecular Weight 209.17
Synonym(s) None
SMILES FC1=CN=C(C=C1)C2=CC=C(C=C2F)F

Computational Chemistry Data

TPSA 12.89
LogP 3.1659
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

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Key Words

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2-(2,4-Difluorophenyl)-5-fluoropyridine

CAS No. 1426047-01-9

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