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CS-W001157 4
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tert-Butyl 4-(piperazin-1-ylmethyl)piperidine-1-carboxylate

  • CAS No. 381722-48-1

  • Cat. No. CS-0111634
  • Purity≥97%
  • MDL No.MFCD09753909

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 4-(piperazin-1-ylmethyl)piperidine-1-carboxylate|CS-0111634

Structure of 381722-48-1

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General Information

  • CAS No. 381722-48-1
  • Cat. No. CS-0111634
  • Purity ≥97%
  • MDL No. MFCD09753909
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₂₉N₃O₂
  • Molecular Weight 283.42
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)N1CCC(CN2CCNCC2)CC1

Description

tert-Butyl 4-(piperazin-1-ylmethyl)piperidine-1-carboxylate features a piperazine-modified piperidine scaffold with a tert-butoxycarbonyl protecting group, enabling straightforward deprotection and functionalization. The pendant piperazinylmethyl moiety offers enhanced solubility and hydrogen-bonding capacity, facilitating integration into bioactive molecules. This compound serves as a key intermediate in the synthesis of CNS-targeted therapeutics and kinase inhibitors.

Application

tert-Butyl 4-(piperazin-1-ylmethyl)piperidine-1-carboxylate serves as a versatile bifunctional building block in medicinal chemistry, enabling efficient access to complex nitrogen-rich scaffolds. The piperazinylmethyl group provides a flexible linker with enhanced solubility and hydrogen-bonding capacity, while the tert-butyl carbamate offers stable protection under standard conditions. It facilitates rapid diversification via orthogonal deprotection and coupling strategies, supporting late-stage functionalization in target-oriented synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3259
Class : 8
Packing Group : Ⅲ
Hazard Statements : H315-H318-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   44.81
  • LogP   1.5387
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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