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CS-W001157 4
Total: USD 88.00

6-Hydroxy-1,2,3,4-tetrahydroquinoline

  • CAS No. 3373-00-0

  • Cat. No. CS-W002691
  • Purity≥96%
  • MDL No.MFCD00800243

*For research and further manufacturing use only, not for direct human use.

6-Hydroxy-1,2,3,4-tetrahydroquinoline|CS-W002691

Structure of 3373-00-0

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General Information

  • CAS No. 3373-00-0
  • Cat. No. CS-W002691
  • Purity ≥96%
  • MDL No. MFCD00800243
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁NO
  • Molecular Weight 149.19
  • Synonym(s) 1,2,3,4-Tetrahydro-quinoline-6-ol
  • SMILES Oc1ccc2c(c1)CCCN2

Description

6-Hydroxy-1,2,3,4-tetrahydroquinoline features a hydroxyl group at the 6-position of a saturated quinoline core, enhancing solubility and enabling direct functionalization. This bench-stable scaffold integrates readily into bioactive molecule synthesis, offering a polar handle for conjugation while maintaining favorable metabolic profile and structural rigidity in drug discovery campaigns.

Application

6-Hydroxy-1,2,3,4-tetrahydroquinoline serves as a versatile scaffold for medicinal chemistry and natural product synthesis, offering a readily accessible phenolic functionality within a saturated quinoline core. Its hydroxyl group enables direct derivatization via etherification, esterification, or metal-catalyzed coupling reactions, while the nitrogen atom supports selective N-functionalization. The compound exhibits good bench stability and facilitates efficient purification by standard chromatographic methods, making it well-suited for iterative synthesis workflows in API development.

Synthesis

  • Route1
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      580-16-5
    • ~%
    • In-stock
      6-Hydroxy-1,2,3,4-tetrahydroquinoline|CS-W002691
      3373-00-0

    References

    • DE42871 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 1, p. 181
  • Route2

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 13 p. 3415 - 3418
  • Route3

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 13 p. 3415 - 3418

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   32.26
  • LogP   1.7503
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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