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CS-W001157 4
Total: USD 88.00

Cyclobutanecarboxylic acid

  • CAS No. 3721-95-7

  • Cat. No. CS-W011325
  • Purity≥98%
  • MDL No.MFCD00001323

*For research and further manufacturing use only, not for direct human use.

Cyclobutanecarboxylic acid|CS-W011325

Structure of 3721-95-7

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General Information

  • CAS No. 3721-95-7
  • Cat. No. CS-W011325
  • Purity ≥98%
  • MDL No. MFCD00001323
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₈O₂
  • Molecular Weight 100.12
  • Synonym(s) cyclobutanecarboxylate; Cyclobutanecarboxylic acid
  • SMILES O=C(C1CCC1)O

Description

Cyclobutanecarboxylic acid features a strained four-membered ring that imparts unique reactivity and conformational rigidity. This structural motif enhances its utility in synthetic routes requiring defined stereochemistry or ring fusion. The carboxylic acid group enables direct functionalization or derivatization under standard conditions, making it valuable for building complex molecular architectures in medicinal chemistry and materials science.

Application

Cyclobutanecarboxylic acid serves as a valuable building block in medicinal chemistry and synthetic organic chemistry, offering a rigid, strained cyclobutane scaffold that enhances metabolic stability and bioavailability in drug candidates. Its carboxylic acid functionality enables direct derivatization into amides, esters, and acyl chlorides, facilitating downstream conjugation and incorporation into complex molecular architectures. The compound exhibits good bench stability and is compatible with standard functional group manipulations, making it well-suited for iterative synthesis workflows and API development.

Synthesis

  • Route1
    • null|null
      1427519-99-0
    • ~0%
    • In-stock
      Cyclobutanecarboxylic acid|CS-W011325
      3721-95-7
    • null|null
      1427520-27-1

    References

    • Rao, Weidong; Sally; Koh, Ming Joo; Chan, Philip Wai Hong Journal of Organic Chemistry, 2013 , vol. 78, # 7 p. 3183 - 3195
  • Route2
    • null|null
      120-92-3
    • ~15%
    • In-stock
      Cyclobutanecarboxylic acid|CS-W011325
      3721-95-7

    References

    • Giurg, Miroslaw; Mlochowski, Jacek Synthetic Communications, 1999 , vol. 29, # 13 p. 2281 - 2291
  • Route3
    • null|null
      2987-17-9
    • ~%
    • In-stock
      Cyclobutanecarboxylic acid|CS-W011325
      3721-95-7

    References

    • van der Maeden,F.P.B. et al. Tetrahedron Letters, 1967 , p. 4521 - 4524

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3265
Class : 8
Packing Group : Ⅲ
Hazard Statements : H227-H314
Precautionary Statements : P210-P260-P264-P280-P301+P330+P331-P304+P340-P363-P370+P378-P403-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   0.8711
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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