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CS-W001157 4
Total: USD 88.00

1-Methylcyclobutanecarboxylic acid

  • CAS No. 32936-76-8

  • Cat. No. CS-W005411
  • Purity≥95%
  • MDL No.MFCD15527494

*For research and further manufacturing use only, not for direct human use.

1-Methylcyclobutanecarboxylic acid|CS-W005411

Structure of 32936-76-8

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General Information

  • CAS No. 32936-76-8
  • Cat. No. CS-W005411
  • Purity ≥95%
  • MDL No. MFCD15527494
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₀O₂
  • Molecular Weight None
  • Synonym(s) 1-Methylcyclobutane-1-carboxylic acid
  • SMILES O=C(C1(C)CCC1)O

Description

1-Methylcyclobutanecarboxylic acid features a rigid cyclobutane ring with a methyl-substituted carboxylic acid group, delivering enhanced steric definition and metabolic stability. This structural motif integrates readily into bioactive scaffolds, offering improved lipophilicity and conformational constraint for medicinal chemistry applications.

Application

1-Methylcyclobutanecarboxylic acid serves as a valuable building block in medicinal chemistry and agrochemical synthesis, offering a rigid, substituted cyclobutane scaffold with enhanced metabolic stability. The carboxylic acid functionality enables direct derivatization to amides, esters, and acyl chlorides, while the adjacent methyl group provides steric differentiation and improved lipophilicity. Its bench-stable nature and compatibility with standard coupling reagents facilitate integration into multi-step synthetic sequences.

Synthesis

  • Route1
    • In-stock
      Cyclobutanecarboxylic acid|CS-W011325
      3721-95-7
    • null|null
      74-88-4
    • ~95%
    • In-stock
      1-Methylcyclobutanecarboxylic acid|CS-W005411
      32936-76-8

    References

    • Cowling, Stephen J.; Goodby, John W. Chemical Communications, 2006 , # 39 p. 4107 - 4109
  • Route2
    • null|null
      74-88-4
    • ~%
    • In-stock
      1-Methylcyclobutanecarboxylic acid|CS-W005411
      32936-76-8

    References

    • WO2006/64336 A2, ; Page/Page column 37 ;
  • Route3

    References

    • WO2006/41797 A2, ; Page/Page column 48 ; WO 2006/041797 A2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3265
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.2612
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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