4-Fluorobenzene-1,2-diamine

Name: 4-Fluorobenzene-1,2-diamine
Brand: ChemScene
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CAS No. 367-31-7
Cat. No. CS-W007604
Purity≥97%
MDL No.MFCD00042228

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 367-31-7
Cat. No. CS-W007604
Purity ≥97%
MDL No. MFCD00042228
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₇FN₂
Molecular Weight 126.13
Synonym(s) Fluoroophenylenediamine
SMILES NC1=CC=C(F)C=C1N

Description

4-Fluorobenzene-1,2-diamine features a fluorinated aromatic ring with adjacent primary amine groups, enabling efficient coupling in pharmaceutical and agrochemical synthesis. The para-fluoro substitution enhances electronic effects and metabolic stability, while the diamine functionality offers dual sites for conjugation. This bench-stable compound integrates readily into complex molecular architectures under standard conditions.

Application

4-Fluorobenzene-1,2-diamine serves as a versatile building block for the synthesis of heterocyclic scaffolds and functionalized arylamines. Its ortho-diamine motif enables efficient cyclization with carbonyl equivalents, facilitating access to substituted quinazolines and other nitrogen-containing heterocycles. The fluorine substituent enhances metabolic stability and modulates electronic properties, offering favorable reactivity in palladium-catalyzed cross-coupling processes. Bench-stable and readily purified by recrystallization, it functions reliably in both medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

TPSA 52.04
LogP 0.9901
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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4-Fluorobenzene-1,2-diamine

CAS No. 367-31-7

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