3,5-Difluorobenzene-1,2-diamine

Name: 3,5-Difluorobenzene-1,2-diamine
Brand: ChemScene
Availability: InStock
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CAS No. 2369-29-1
Cat. No. CS-W021815
Purity≥98%
MDL No.MFCD00973899

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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3,5-Difluorobenzene-1,2-diamine|CS-W021815

Structure of 2369-29-1

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General Information

CAS No. 2369-29-1
Cat. No. CS-W021815
Purity ≥98%
MDL No. MFCD00973899
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₆F₂N₂
Molecular Weight 144.12
Synonym(s) 3,5-Difluoro-1,2-benzenediamine
SMILES NC1=CC(F)=CC(F)=C1N

Description

3,5-Difluorobenzene-1,2-diamine features a symmetrically substituted aromatic core with two fluorine atoms at the 3 and 5 positions, enhancing electronic effects while maintaining stability. The ortho-diamine functionality enables direct incorporation into heterocyclic systems, offering high reactivity in transition metal-catalyzed coupling and cyclization reactions. This bench-stable derivative serves as a key building block for advanced pharmaceutical intermediates and functional materials.

Application

3,5-Difluorobenzene-1,2-diamine serves as a versatile building block in medicinal chemistry and materials science, enabling the construction of fluorinated heterocycles via cyclization reactions. Its ortho-diamine functionality facilitates metal-catalyzed coupling processes and Schiff base formation, while the 3,5-difluoro substitution pattern enhances metabolic stability and modulates electronic properties. The compound exhibits good bench stability and is compatible with standard purification techniques, making it well-suited for iterative synthesis workflows.

Synthesis

Route1
- 364-30-7
- ~88%
- In-stock
  
  2369-29-1
References
- Dener, Jeffrey M.; O'Bryan, Colin; Yee, Robert; Shelton, Emma J.; Sperandio, David; Mahajan, Tania; Palmer, James T.; Spencer, Jeffrey R.; Tong, Zhiwei Tetrahedron Letters, 2006 , vol. 47, # 27 p. 4591 - 4595
Route2
- In-stock
  
  399-36-0
- ~%
- In-stock
  
  2369-29-1
References
- Journal of the American Chemical Society, , vol. 73, p. 153 Journal of the American Chemical Society, , vol. 81, p. 94,98

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 52.04
LogP 1.1292
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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3,5-Difluorobenzene-1,2-diamine

CAS No. 2369-29-1

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