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CS-W001157 4
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Ethyl 4-amino-2-methylpyrimidine-5-carboxylate

  • CAS No. 5472-46-8

  • Cat. No. CS-0045752
  • Purity≥98%
  • MDL No.MFCD05721220

*For research and further manufacturing use only, not for direct human use.

Ethyl 4-amino-2-methylpyrimidine-5-carboxylate|CS-0045752

Structure of 5472-46-8

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General Information

  • CAS No. 5472-46-8
  • Cat. No. CS-0045752
  • Purity ≥98%
  • MDL No. MFCD05721220
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₁N₃O₂
  • Molecular Weight 181.19
  • Synonym(s) methyl 4-amino-2-methylpyrimidine-5-carboxylate
  • SMILES O=C(C1=CN=C(C)N=C1N)OCC

Description

Ethyl 4-amino-2-methylpyrimidine-5-carboxylate features a pyrimidine core functionalized with amino and methyl groups at the 4- and 2-positions, respectively, and a carboxylate ester at the 5-position. This configuration enables straightforward derivatization in medicinal chemistry, particularly for heterocyclic scaffolds. The compound exhibits favorable solubility in polar organic solvents and stability under standard bench conditions.

Application

Ethyl 4-amino-2-methylpyrimidine-5-carboxylate serves as a versatile building block in heterocyclic synthesis, enabling efficient access to pyrimidine-based scaffolds through standard functional group manipulations. The amino and carboxylate groups provide orthogonal reactivity for derivatization, while the methyl substituent enhances stability and facilitates selective transformations. Its bench-stable nature and compatibility with common coupling and cyclization protocols make it ideal for medicinal chemistry campaigns and API intermediate development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   78.1
  • LogP   0.54392
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   2

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