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CS-W001157 4
Total: USD 88.00

3-Fluorobenzene-1,2-diamine

  • CAS No. 18645-88-0

  • Cat. No. CS-W019866
  • Purity≥95%
  • MDL No.MFCD00061130

*For research and further manufacturing use only, not for direct human use.

3-Fluorobenzene-1,2-diamine|CS-W019866

Structure of 18645-88-0

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General Information

  • CAS No. 18645-88-0
  • Cat. No. CS-W019866
  • Purity ≥95%
  • MDL No. MFCD00061130
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇FN₂
  • Molecular Weight None
  • Synonym(s) 2-Amino-3-fluoroaniline; 3-Fluoro-1,2-diaminobenzene; 3-Fluoro-1,2-phenylenediamine; 2,3-DIAMINOFLUOROBENZENE
  • SMILES NC1=CC=CC(F)=C1N

Description

3-Fluorobenzene-1,2-diamine features a fluorinated aromatic ring with adjacent primary amine groups, enabling direct incorporation into azo dyes, pharmaceutical intermediates, and functional materials. The electron-withdrawing fluorine enhances reactivity in coupling processes while maintaining stability under standard conditions.

Application

3-Fluorobenzene-1,2-diamine serves as a versatile building block for the synthesis of fluorinated heterocycles and bioactive scaffolds. Its ortho-diamine functionality enables efficient cyclization with carboxylic acid derivatives, aldehydes, and electrophiles to construct quinazolines, benzimidazoles, and other nitrogen-containing ring systems. The molecule exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative medicinal chemistry campaigns and process development workflows.

Synthesis

  • Route1

    References

    • Kawamoto, Kyoko; Uchiyama, Seiichi Chemistry Letters, 2012 , vol. 41, # 11 p. 1451 - 1452
  • Route2
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    • In-stock
      3-Fluorobenzene-1,2-diamine|CS-W019866
      18645-88-0

    References

    • Journal of Fluorine Chemistry, , vol. 42, p. 245 - 256
  • Route3

    References

    • Journal of Fluorine Chemistry, , vol. 42, p. 245 - 256

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P301+P310-P330-P501

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Computational Chemistry Data

  • TPSA   52.04
  • LogP   0.9901
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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