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CS-W001157 4
Total: USD 88.00

3-Fluoro-2-nitroaniline

  • CAS No. 567-63-5

  • Cat. No. CS-W001162
  • Purity≥96%
  • MDL No.MFCD07368750

*For research and further manufacturing use only, not for direct human use.

3-Fluoro-2-nitroaniline|CS-W001162

Structure of 567-63-5

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General Information

  • CAS No. 567-63-5
  • Cat. No. CS-W001162
  • Purity ≥96%
  • MDL No. MFCD07368750
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅FN₂O₂
  • Molecular Weight 156.11
  • Synonym(s) None
  • SMILES [O-][N+](=O)c1c(N)cccc1F

Description

3-Fluoro-2-nitroaniline features a fluorine atom at the meta position relative to an electron-deficient nitro group, enhancing its reactivity in nucleophilic substitution and coupling reactions. This bench-stable aromatic amine integrates readily into complex molecular architectures under standard conditions.

Application

3-Fluoro-2-nitroaniline serves as a key intermediate in the synthesis of fluorinated heterocycles and pharmaceutical scaffolds. Its ortho-nitro group enables directed metalation, while the fluoro substituent provides enhanced metabolic stability and modulates electronic properties. The compound exhibits good bench stability and facilitates efficient coupling reactions, making it valuable for medicinal chemistry campaigns requiring electron-deficient aromatic building blocks.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   69.16
  • LogP   1.3161
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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