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CS-W001157 4
Total: USD 88.00

2-Benzylpyrazol-3-amine

  • CAS No. 3528-51-6

  • Cat. No. CS-0060524
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Benzylpyrazol-3-amine|CS-0060524

Structure of 3528-51-6

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General Information

  • CAS No. 3528-51-6
  • Cat. No. CS-0060524
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₁N₃
  • Molecular Weight 173.21
  • Synonym(s) 5-amino-1-phenylmethylpyrazole
  • SMILES C1=CC=C(C=C1)CN2C(=CC=N2)N

Description

1-Benzyl-1H-pyrazol-5-amine features a pyrazole core functionalized with a benzyl group at N1 and an amino substituent at C5, delivering enhanced solubility and stability. This scaffold integrates readily into bioactive molecule design, offering a robust platform for pharmaceutical development. The para-amino group enables direct coupling reactions under standard conditions.

Application

1-Benzyl-1H-pyrazol-5-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive heterocycles through standard functionalization at the pyrazole nitrogen and benzyl ring. Its bench-stable nature and compatibility with common coupling reactions facilitate rapid diversification for scaffold exploration.

Synthesis

  • Route1
    • null|null
      100-52-7
    • null|null
      107-13-1
    • ~13%
    • In-stock
      2-Benzylpyrazol-3-amine|CS-0060524
      3528-51-6

    References

    • GLAX0SMITHKLINE LLC; BURGESS, Joelle, Lorraine; JOHNSON, Neil, W.; KNIGHT, Steven, David; LAFRANCE, Louis, Vincent, III; MILLER, William, H.; NEWLANDER, Kenneth, Allen; ROMERIL, Stuart, Paul; ROUSE, Meagan, B.; SUAREZ, Dominic; TIAN, Xinrong; VERMA, Sharad, Kumar Patent: WO2013/39988 A1, 2013 ; Location in patent: Page/Page column 133 ;
  • Route2
    • null|null
      137968-21-9
    • ~60%
    • In-stock
      2-Benzylpyrazol-3-amine|CS-0060524
      3528-51-6
    • null|null
      137968-29-7

    References

    • Journal of Organic Chemistry, , vol. 57, # 5 p. 1563 - 1567
  • Route3
    • null|null
      1202-58-0
    • ~%
    • In-stock
      2-Benzylpyrazol-3-amine|CS-0060524
      3528-51-6

    References

    • Journal of Combinatorial Chemistry, , vol. 12, # 4 p. 510 - 517

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   43.84
  • LogP   1.5136
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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