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CS-W001157 4
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1-Methyl-1H-pyrazol-5-ylamine

  • CAS No. 1192-21-8

  • Cat. No. CS-D1362
  • Purity≥98%
  • MDL No.MFCD00068156

*For research and further manufacturing use only, not for direct human use.

1-Methyl-1H-pyrazol-5-ylamine|CS-D1362

Structure of 1192-21-8

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General Information

  • CAS No. 1192-21-8
  • Cat. No. CS-D1362
  • Purity ≥98%
  • MDL No. MFCD00068156
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₇N₃
  • Molecular Weight 97.12
  • Synonym(s) 1-methyl-1H-pyrazol-5-amine; 1-Methyl-1H-pyrazol-5-ylamine
  • SMILES NC1=CC=NN1C

Application

1-Methyl-1H-pyrazol-5-ylamine serves as a versatile building block in medicinal chemistry, enabling efficient access to functionalized pyrazole scaffolds. Its primary amine functionality facilitates direct coupling reactions, while the methyl group enhances metabolic stability and modulates solubility. The compound exhibits excellent bench stability and compatibility with standard synthetic protocols, supporting broad functional group tolerance and straightforward purification. It functions as a key intermediate in the construction of heterocyclic APIs and bioactive molecules.

Synthesis

  • Route1
    • null|null
      60838-50-8
    • null|null
      60-34-4
    • ~94%
    • In-stock
      1-Methyl-1H-pyrazol-5-ylamine|CS-D1362
      1192-21-8

    References

    • Bagley, Mark C.; Baashen, Mohammed; Paddock, Victoria L.; Kipling, David; Davis, Terence Tetrahedron, 2013 , vol. 69, # 39 p. 8429 - 8438
  • Route2

    References

    • WO2005/30758 A1, ; Page/Page column 60-61 ; WO 2005/030758 A1
  • Route3

    References

    • Lynch; Khan; Teo; Pedrotti Canadian Journal of Chemistry, 1988 , vol. 66, # 3 p. 420-428

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   43.84
  • LogP   0.0023
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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